Nucleic acid binding behaviors and cytotoxic properties of a Ru(II) complex |
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Authors: | Tan Li-Feng Song Fu-Cang Zou Xiao-Qin Ling Xi-Ling |
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Affiliation: | Key Laboratory of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan, PR China. lfwyxh@yahoo.com.cn |
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Abstract: | The interactions of complex [Ru(bpy)(2)(hnip)](2+) (1) {bpy?=?2,2'-bipyridine, hnip?=?2-(2-hydroxy-1-naphthyl)imidazo[4,5-f][1,10]phenanthroline} with calf thymus DNA and yeast tRNA were investigated by UV-vis spectroscopy, fluorescence spectroscopy, viscosity, equilibrium dialysis, and circular dichroism. In addition, the antitumor activities of complex 1 were evaluated with MTT method. These results indicate that the structures of DNA and RNA have significant effects on the binding behaviors of complex 1. Further, complex 1 demonstrates different antitumor activities against selected cancer cell lines in vitro. |
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