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湖南汉族人群MICB等位基因多态性与白血病的相关性研究
引用本文:罗奇志,龚拯,余平,林琳,王芙艳,霍治. 湖南汉族人群MICB等位基因多态性与白血病的相关性研究[J]. 激光生物学报, 2012, 21(3): 224-232
作者姓名:罗奇志  龚拯  余平  林琳  王芙艳  霍治
作者单位:罗奇志 (中南大学基础医学院免疫学系,湖南长沙,410078) ; 龚拯 (中南大学基础医学院免疫学系,湖南长沙,410078) ; 余平 (中南大学基础医学院免疫学系,湖南长沙,410078) ; 林琳 (中南大学基础医学院免疫学系,湖南长沙,410078) ; 王芙艳 (中南大学基础医学院免疫学系,湖南长沙,410078) ; 霍治 (中南大学基础医学院免疫学系,湖南长沙,410078) ;
摘    要:目的:研究湖南汉族人群MICB等位基因的多态性与白血病的相关性。方法:MICB等位基因分型用PCR-SSP和PCR-SBT的方法。结果:白血病患者中有13种MICB等位基因被检测出,其中MICB*005:02/010基因频率较对照组显著偏低(OR=0.416,P<0.05)。不同类别白血病之间MICB等位基因多态性没有显著差异。结论:MICB*005:02/010等位基因可能与白血病的保护相关。

关 键 词:MICB基因  基因多态性  白血病

A Study on the Correlation between MICB Alleles Polymorphism and Leukemia in Hunan Han Population
LUO Qizhi,GONG Zheng,. YU Ping,LIN Lin,WANG Fuyan,HUO Zhi. A Study on the Correlation between MICB Alleles Polymorphism and Leukemia in Hunan Han Population[J]. ACTA Laser Biology Sinica, 2012, 21(3): 224-232
Authors:LUO Qizhi  GONG Zheng  . YU Ping  LIN Lin  WANG Fuyan  HUO Zhi
Affiliation:(The Department of Immunology, School of Basic Medical Science, Central South University, Changsha 410078, Hunan, China)
Abstract:Objective : To study on the polymorphism of M1CB and its correlation with leukemia in Hunan Han population. Methods:PCR-SSP and PCR-SBT were used to analyze the gene polymorphism of MICB. Results:13 allelic genes were found in patients of leukemia, and the frequency of MICB * 005:02/010 was significantly lower than that of control group (OR = 0. 416, P 〈 0.05 ). There was no significant difference of MICB gene frequency between different types of leukemia. Conclusions:MICB * 005:02/010 allelic gene polymorphisms may be associated with leukemia protection.
Keywords:MICB alleles  gene polymorphism  leukemia
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