Two major metabolites of 8-prenylnaringenin are estrogenic in vitro |
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Authors: | Zierau Oliver Hauswald Stefanie Schwab Pia Metz Peter Vollmer Günter |
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Institution: | Institute of Zoology, Dresden University of Technology, D-01062 Dresden, Germany. |
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Abstract: | 8-prenylnaringenin (8-PN) and preparations containing 8-prenylnaringenin have been suggested for use in medicinal and cosmetic applications like hormone replacement or bust enhancement. However, the safety of application is still under considerable debate. Recently it has been shown that human liver microsomes are converting 8-prenylnaringenin to 12 metabolites, with (E)-8-(4'-hydroxyisopentenyl)naringenin (8-PN-OH) and (E)-8-(4'-oxoisopentenyl)naringenin (8-PN=O) being among the most abundant. Applying two independent in vitro test systems we demonstrate that these two metabolites of 8-prenylnaringenin are estrogenic in vitro. These results represent an important piece of information towards the discussion of safety of use of preparations containing 8-prenylnaringenin. |
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