Inhibition of the aspartic proteinase from HIV-2 |
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| Authors: | A D Richards A V Broadhurst A J Ritchie B M Dunn J Kay |
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| Institution: | Dept of Biochemistry, University of Wales College of Cardiff. |
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| Abstract: | Kinetic constants were determined for the interaction of the HIV-2 aspartic proteinase with a synthetic substrate and a number of inhibitors at several pH values. Acetyl-pepstatin was more effective towards HIV-2 proteinase than the renin inhibitor, H-261; this effect is exactly the opposite from that observed previously for the proteinase from the HIV-1 AIDS virus. |
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