Macroporous gel particles as robust macroporous matrices for cell immobilization |
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Authors: | Plieva Fatima M Oknianska Alina Degerman Eva Mattiasson Bo |
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Institution: | Department of Biotechnology, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden. fatima.plieva@biotek.lu.se |
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Abstract: | A new design of robust matrices for cell immobilization is described. Macroporous gels (MGs) with immobilized microbial cells were prepared at subzero temperatures and were formed inside a plastic core (so-called, protective housing). Due to the protective housing the macroporous gel particles with immobilized cells can be used in well-stirred bioreactors. High retained activity of yeast (77-92%) and Escherichia coli (50-91%) cells immobilized in MGs after drying and storage in the dried state was due to the high structural stability and heterogeneous porous structure of the MGs. |
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Keywords: | Cell immobilization Cell storage Gryogel Macroporous gel particles (MGPs) Poly(vinyl alcohol) |
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