Hesperidin inhibits expression of hypoxia inducible factor-1 alpha and inflammatory cytokine production from mast cells |
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Authors: | In-Young Choi Su-Jin Kim Hyun-Ja Jeong Seong-Heak Park Yong-Sun Song Ji-Hyun Lee Tae-Hee Kang Jin-Han Park Gab-Soo Hwang Eon-Jeong Lee Seung-Heon Hong Hyung-Min Kim Jae-Young Um |
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Affiliation: | (1) College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea;(2) College of Pharmacy, VCRC of Wonkwang University, Iksan, Republic of Korea;(3) College of Oriental Medicine, Wonkwang University, Iksan, Republic of Korea;(4) Department of Medicinal Herb Development, Gyeongju University, San 42-1 Hyohyun-dong, Gyeongju, Gyeong-buk, 780-712, Republic of Korea;(5) School of Civil and Environmental Engineering, Kunsan National University, 68 Miryong-dong, Kunsan, Jeonbuk, 573-701, Republic of Korea |
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Abstract: | The citrus unshiu peel has been used traditionally as a medicine to improve bronchial and asthmatic conditions or cardiac and blood circulation in Korea, China, and Japan. Here, we report the effects of citrus unshiu peel water extract (CPWE) on the phorbol myristate acetate (PMA) + calcium ionophore A23187-induced hypoxia-inducible factor-1α (HIF-1α) activation and inflammatory cytokine production from the human mast cell line, HMC-1 cells. We compared CPWE with hesperidin, a common constituent of citrus unshiu. CPWE and hesperidin inhibited the PMA + A23187-induced HIF-1α expression and the subsequent production of vascular endothelial growth factor (VEGF). In addition, CPWE suppressed PMA + A23187-induced phosphorylation of the extracellular signal-regulated kinase (ERK). We also show that the increased cytokines interleukin (IL)-1β, IL-8, and tumor necrosis factor (TNF)-α level was significantly inhibited by treatment of CPWE or hesperidin. In the present study, we report that CPWE and hesperidin are inhibitors of HIF-1α and cytokines on the mast cell-mediated inflammatory responses. |
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Keywords: | Citrus unshiu peel water extract Hesperidin Hypoxia-inducible factor-1α Cytokines Mast cells |
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