Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster |
| |
Authors: | Vognsen Tina Kristensen Ole |
| |
Institution: | Biostructural Research, Department of Drug Design and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. tv@farma.ku.dk |
| |
Abstract: | The crystal structure of the NTF2-like domain of the Drosophila homolog of Ras GTPase SH3 Binding Protein (G3BP), Rasputin, was determined at 2.7 Å resolution. The overall structure is highly similar to nuclear transport factor 2: It is a homodimer comprised of a β-sheet and three α-helices forming a cone-like shape. However, known binding sites for RanGDP and FxFG containing peptides show electrostatic and steric differences compared to nuclear transport factor 2. A HEPES molecule bound in the structure suggests a new, and possibly physiologically relevant, ligand binding site. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|