Attractive guidance: how the chemokine SDF1/CXCL12 guides different cells to different locations |
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| Authors: | Lewellis Stephen W Knaut Holger |
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| Affiliation: | Developmental Genetics Program, Institute of Biomolecular Medicine, New York University, Langone Medical Center, New York, NY 10016, USA. |
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| Abstract: | During the development and adult life of multicellular organisms cells move from one location to another as they assemble into organs, seal a wound or fight pathogens. For navigation, migrating cells follow cues that guide them to their final position. Frequently, a single cue simultaneously guides different cells to different positions. Recent studies of one such cue-the chemokine SDF1-suggest strategies for how the animal achieves this task without causing erroneous migration. |
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