Phosphonium lipocations as antiparasitic agents |
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| Authors: | Long Timothy E Lu Xiao Galizzi Melina Docampo Roberto Gut Jiri Rosenthal Philip J |
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| Affiliation: | Department of Pharmaceutical and Biomedical Sciences and Center for Drug Discovery, University of Georgia, Athens, GA 30602, USA. tlong@rx.uga.edu |
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| Abstract: | Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low μM concentrations against T. cruzi. |
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