| 抗H9亚型流感病毒HA抗血清对小鼠的被动免疫预防和治疗研究 |
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| 引用本文： | 徐芙好,黄恋,杨忠东,常海艳,方芳,陈则. 抗H9亚型流感病毒HA抗血清对小鼠的被动免疫预防和治疗研究[J]. 生命科学研究, 2010, 14(2): 141-145 |
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| 作者姓名： | 徐芙好 黄恋 杨忠东 常海艳 方芳 陈则 |
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| 作者单位： | 湖南师范大学生命科学学院,中国湖南,长沙,410081;上海生物制品所,中国,上海,200052;湖南师范大学生命科学学院,中国湖南,长沙,410081;上海生物制品所,中国,上海,200052 |
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| 基金项目： | 湖南省教育厅创新平台开放基金资助项目,湖南师范大学青年基金资助项目 |
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| 摘 要： | H9亚型流感病毒是引起大流感的潜在威胁.抗血清被动免疫是一种有效的应对流感的方法.采用H9N2禽流感病毒血凝素(hemagglutinin,HA)DNA重组质粒免疫BALB/c小鼠制备抗血清.在致死量同源病毒感染前或后通过尾静脉给小鼠注射不同剂量抗血清,观察小鼠14d内的体重丢失率和死亡率.结果显示,1280血凝抑制单位(hemagglutination Inhibition unit,HIU)抗血清可给小鼠提供至少长达11d的100%预防和1d的80%治疗保护.HA DNA疫苗免疫制备的抗血清可以有效地抵抗同源H9病毒的致死攻击,在H9病毒感染的预防和治疗中发挥作用.
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| 关 键 词： | 流感 H9亚型 抗血清 免疫预防 治疗 |
Prophylaxis and Treatment of H9 Infection in Mice with Anti-H9 HA Serum |
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| XU Fu-yu,HUANG Lian,YANG Zhong-dong,CHANG Hai-yan,FANG Fang,CHEN Ze. Prophylaxis and Treatment of H9 Infection in Mice with Anti-H9 HA Serum[J]. Life Science Research, 2010, 14(2): 141-145 |
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| Authors: | XU Fu-yu HUANG Lian YANG Zhong-dong CHANG Hai-yan FANG Fang CHEN Ze |
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| Affiliation: | XU Fu-yu1,HUANG Lian2,YANG Zhong-dong1,CHANG Hai-yan1,FANG Fang1,CHEN Ze1,2(1.College of Life Sciences,Hunan Normal University,Changsha 410081,Hunan,China,2.Shanghai Institute of Biological Products,Shanghai 200052,China) |
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| Abstract: | Influenza H9 subtype virus is a potential threat as it can cause pandemic influenza.Passive immunization with antiserum is an effective way against influenza.Antiserum was produced by immunization of BALB/c mice with H9N2 HA recombinant plasmid.Mice interventrally(i.v.)received different doses of antiserum at different days prior to-or post-lethal challenge with homologous virus.Efficacy was determined by observation of survival of mice as well as weight loss.Results showed that 1 280 HIU dose of antiserum ... |
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| Keywords: | influenza H9 subtype antiserum immunoprophylaxis therapy |
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