Sequence deduced physical properties in the D-loop region common to five vertebrate mitochondrial DNAs |
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Authors: | B Mignotte D Dunon-Bluteau C Reiss J C Mounolou |
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Affiliation: | Laboratoire de Biologie Générale, Université de Paris-Sud, Orsay, France. |
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Abstract: | Some sequence-induced physical properties of the region of the replication origin in human, mouse, rat, ox and xenopus mitochondrial DNA have been studied: characteristic profiles of stability can be observed, a consensus pattern of hydrogen bond donor/acceptor associated to a symmetrical distribution of base roll angles variation is found upstream of the 5' ends of the D-loop strand. In spite of diversity, evolution has conserved the collective physical properties in parts of the origin of replication region suggesting specific functions for these non-coding sequences. |
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