The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers |
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| Authors: | Melinda Larsen Steven J Ressler Michael J Gerdes Bing Lu Meg Byron Jeanne B Lawrence David R Rowley |
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| Institution: | (1) Cell and Molecular Biology Program, Baylor College of Medicine, Houston, Texas 77030, USA, US;(2) Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA, US;(3) Department of Cell Biology, University of Massachusetts Medical School, 53 Lake Avenue North, Worcester, Massachusetts 01655, USA, US |
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| Abstract: | We previously identified ps20 protein as a secreted growth inhibitor and purified the protein from fetal rat prostate urogenital
sinus mesenchymal cell conditioned medium. The rat cDNA was subsequently cloned, and ps20 was found to contain a WAP-type
four-disulfide core motif, indicating it may function as a protease inhibitor. We now report cloning and characterization
of the mouse ps20 gene (designated Wfdc1), the human homolog cDNA, and the human gene (designated WFDC1). Both the mouse and human WFDC1 genes consist of seven exons
and encode respective ps20 proteins sharing 79.1% identity and nearly identical WAP motifs in exon 2. The WFDC1 gene was mapped
by FISH analysis to human Chromosome (Chr) 16q24, an area of frequent loss of heterozygosity (LOH) previously identified in
multiple cancers including prostate, breast, hepatocellular, and Wilms' tumor. Identification and characterization of the
WFDC1 gene may aid in better understanding the potential role of this gene and ps20 in prostate biology and carcinogenesis. |
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