| Scrib复合物和Par复合物——从细胞极性调控到肿瘤发生 |
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| 引用本文： | 朱明伟,辛天池,李琦,李明发.Scrib复合物和Par复合物——从细胞极性调控到肿瘤发生[J].细胞生物学杂志,2010(2). |
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| 作者姓名： | 朱明伟 辛天池 李琦 李明发 |
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| 作者单位： | 上海交通大学生命科学技术学院遗传发育与精神神经疾病教育部重点实验室; |
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| 基金项目： | 国家自然科学基金(No.30871409,No.30800648); 上海市自然科学基金(No.10ZR1414700)资助~~ |
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| 摘 要： | 上皮细胞和组织发生癌变时,通常会伴随细胞极性丧失和组织结构紊乱的现象。然而,极性丧失对肿瘤发生的贡献却一直存在争论。随着控制上皮细胞顶-底极性分子机制的逐步揭示,人们发现,这一极性机制与肿瘤发生联系紧密。上皮细胞顶-底极性的确立主要依赖于顶膜区Par复合物与底侧膜区Scrib复合物之间的拮抗。当Scrib复合物活性下调或Par复合物活性上调时,两复合物间的这种相互制约的平衡就会被打破,从而导致肿瘤发生。本文主要综述Scrib复合物和Par复合物如何参与上皮细胞顶-底极性的建立,以及两者间的互作与肿瘤发生的关系。
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| 关 键 词： | 上皮细胞顶-底极性 Scrib复合物 Par复合物 肿瘤发生 |
Scrib Complex and Par Complex:From Apical-basal Polarity to Tumorigenesis |
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| Ming-Wei Zhu,Tian-Chi Xin,Qi Li,Ming-Fa Li.Scrib Complex and Par Complex:From Apical-basal Polarity to Tumorigenesis[J].Chinese Journal of Cell Biology,2010(2). |
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| Authors: | Ming-Wei Zhu Tian-Chi Xin Qi Li Ming-Fa Li |
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| Institution: | Ming-Wei Zhu,Tian-Chi Xin,Qi Li,Ming-Fa Li~* (MoE Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases,School of Life Science and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China) |
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| Abstract: | Loss of cell polarity is commonly observed in most human cancers derived from epithelial tissues.However,the contribution of cell polarity disruption to tumor progression has been unknown.Recently,the molecular mechanisms that control cellular polarization were gradually uncovered.Meanwhile,it was found that this molecular machinery is intimately involved in tumorigenesis.During the formation of apical-basal cell polarity,Scrib complex and Par complex antagonize reciprocally to determine the apical and baso... |
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| Keywords: | apical-basal cell polarity Scrib complex Par complex tumorigenesis |
| 本文献已被 CNKI 等数据库收录！ |
