Fine structure of growth cones in the upper dorsal horn of the adult primate spinal cord in the course of reactive synapto-neogenesis |
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Authors: | Elizabeth Knyihár-Csillik Pasko Rakic Prof Bert Csillik MD PhD ScD |
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Institution: | (1) Department of Anatomy, University Medical School, Szeged, Hungary;(2) Section of Neuroanatomy, School of Medicine, Yale University, New Haven, USA;(3) Dept. of Anatomy, University Medical School, Kossuth Lajos sgt. 40, P.O. Box 512, H-6701 Szeged, Hungary |
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Abstract: | Summary Following transganglionic degenerative atrophy of primary afferent terminals induced by a crush-injury of the sciatic nerve, a regenerative process takes places in the upper dorsal horn of the lumbar spinal cord in the primate Macacus rhesus. Axonal growth cones are characterized by cisterns of axoplasmic reticulum; filopodia emanating from growth cones are electron-optically translucent sheet-like expansions, often containing growth-cone vesicles. Axoplasmic reticulum appears also in preterminal portions of regenerating axons. Dendritic growth cones contain a fine, filamentous matrix; electron-dense membrane specializations can be seen in well-defined areas of their surfaces. Immature synapses are formed between filopodia of axonal growth cones and dendritic growth cones. Electron-microscopic structures of this unique CNS regeneration are similar to those seen in the course of embryonic development of the spinal cord. |
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Keywords: | Spinal cord Regeneration in CNS Synapse formation Growth cone Rhesus monkey |
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