L-rhamnose and L-fucose suppress cancer growth in mice |
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Authors: | Pavel Tomsik Tomas Soukup Eva Cermakova Stanislav Micuda Mohamed Niang Lenka Sucha Martina Rezacova |
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Institution: | (1) Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi Tokyo, 194-8533, Japan |
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Abstract: | It is documented that deficient fucosylation may play an important role in the pathogenesis of cancer. Since the supplementation
of L-fucose could restore fucosylation in both in vitro and in vivo conditions, our intent was to examine the effect of intraperitoneal administration of L-fucose and L-rhamnose (a similar
deoxysaccharide) on tumour growth, mitotic activity and metastatic setting of a solid form of Ehrlich carcinoma as well as
on the survival rate of tumour bearing mice. Both L-fucose and L-rhamnose exerted a significant suppressive effect on tumour
growth (P<0.05). After 10 days of therapy, the greatest inhibition of tumour growth expressed as a percentage of controls
was observed in L-rhamnose at a dose of 3 g/kg/day (by 62%) and L-fucose at a dose of 5 g/kg/day (by 47%). Moreover, the mitotic
index decreased with increasing doses of L-fucose and L-rhamnose. Prolonged survival of tumour bearing mice was observed after
14 consecutive days of daily administering L-rhamnose. Its optimal dose was estimated to be 3.64 g/kg/day. L-Fucose, however,
displayed only a slight effect on the survival of the mice. Our results suggest that L-fucose and especially L-rhamnose have
anticancer potential. This study is the first to demonstrate the tumour-inhibitory effect of L-rhamnose. |
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