Frequency of lactase persistence genotype in a healthy Polish population |
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Authors: | Tomasz Płoszaj Krystyna Jędrychowska-Dańska Henryk W Witas |
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Institution: | (1) Department of Genetics Evolution and Environment, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK; |
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Abstract: | The majority of mammals are unable to digest lactose due to post-weaning deactivation of the LCT gene, which is responsible for encoding the enzyme lactase (i.e., adult-type hypolactasia). A substitution of C with T at position −13910 bp upstream of the LCT gene has been linked to the lactase persistence phenotype in European populations. We investigated the frequency of LCT-13910C>T
polymorphism in 223 blood donors from central Poland. All samples were genotyped by polymerase chain reaction and direct sequencing.
The LCT-13910 T allele (lactase persistence) was present in 51% of individuals sampled from the Polish population. We did
not find any non-European variants associated with lactase persistence (LCT-13907C>G, LCT-13913T>C, LCT-13915T>G), or any
new polymorphisms within the sequenced region. Allele frequencies obtained are in agreement with results from other countries
and confirm the unique pattern of distribution of the LCT-13910C>T genotype in Europe. |
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Keywords: | |
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