Pros and Cons of Extrapolating Animal Data on Antifungal Pharmacodynamics to Humans |
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Authors: | Scott W Mueller Tyree H Kiser |
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Institution: | 2. Department of Clinical Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO, USA 1. Department of Clinical Pharmacy, University of Colorado Anschutz Medical Campus, 12850 E. Montview Blvd, Mail Stop C238, Aurora, CO, 80045, USA
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Abstract: | Both the incidence of invasive fungal infections and the number of antifungal agents available to clinicians have expanded
significantly over the past two decades. Successes with pharmacokinetic and pharmacodynamic evaluations of other antimicrobial
agents in animal models and their clinical correlations with patient outcomes have led to an increased number of studies evaluating
both old and new antifungal agents. Recently, animal models have successfully defined target pharmacodynamic indices for many
antifungal agents and fungal infections, but validation of these targets in human studies is frequently lacking. This article
evaluates the potential pros and cons of extrapolating to humans the animal data on antifungal pharmacodynamics. |
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