Evidence that monoclonal antibody production kinetics is related to the integral of the viable cells curve in batch systems |
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| Authors: | J. M. Renard R. Spagnoli C. Mazier M. F. Salles E. Mandine |
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| Affiliation: | (1) Microbiology and Fermentation Research Unit Department of Biotechnology, Roussel-Uclaf, 93230 Romainville, France;(2) Laboratoires Cassenne, 95520 Osny, France |
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| Abstract: | Summary Monoclonal antibody production kinetics in batch systems is linearly related to the integral of the viable cells curve. This favors the secretion theory over that of release by dead cells. Regression of the production curve over the integral of the viable cells curve in different media can also give information on the nutritional requirements of the cells for growth and production. |
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