Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists |
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Authors: | McCalmont William F Heady Tiffany N Patterson Jaclyn R Lindenmuth Michael A Haverstick Doris M Gray Lloyd S Macdonald Timothy L |
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Affiliation: | Department of Chemistry, University of Virginia, Charlottesville, VA 22904-4319, USA. wfm3s@virginia.edu |
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Abstract: | This paper describes the synthesis of several novel T-type calcium channel antagonists that inhibit calcium influx into the cell, which in turn regulates unknown aspects of the cell cycle pathway that are responsible for cellular proliferation. A library of compounds was synthesized and a brief structure activity relationship will be described. From these studies we have identified a compound (1) that displays anti-proliferative activity in the low micromolar range across a variety of cancer cell lines. |
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