Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin |
| |
Authors: | Temmerman Stéphane Pethe Kevin Parra Marcela Alonso Sylvie Rouanet Carine Pickett Thames Drowart Annie Debrie Anne-Sophie Delogu Giovanni Menozzi Franco D Sergheraert Christian Brennan Michael J Mascart Françoise Locht Camille |
| |
Affiliation: | Laboratory of Immunology, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik, 808, B-1070 Brussels, Belgium. |
| |
Abstract: | Although post-translational modifications of protein antigens may be important componenets of some B cell epitopes, the determinants of T cell immunity are generally nonmodified peptides. Here we show that methylation of the Mycobacterium tuberculosis heparin-binding hemagglutinin (HBHA) by the bacterium is essential for effective T cell immunity to this antigen in infected healthy humans and in mice. Methylated HBHA provides high levels of protection against M. tuberculosis challenge in mice, whereas nonmethylated HBHA does not. Protective immunity induced by methylated HBHA is comparable to that afforded by vaccination with bacille Calmette et Guérin, the only available anti-tuberculosis vaccine. Thus, post-translational modifications of proteins may be crucial for their ability to induce protective T cell-mediated immunity against infectious diseases such as tuberculosis. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|