| 神经元迁移的细胞和分子机制 |
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| 引用本文： | 吴平,宋淑亮,王允山,梁浩,王伟莉,吉爱国. 神经元迁移的细胞和分子机制[J]. 生命的化学, 2010, 0(2) |
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| 作者姓名： | 吴平 宋淑亮 王允山 梁浩 王伟莉 吉爱国 |
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| 作者单位： | 山大威海国际生物技术研发中心;山东大学药学院; |
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| 摘 要： | 在脑的发育过程中,神经元的正确迁移是正常脑组织发生的一个必不可少的环节。在过去的几十年中,通过不同的学科方法,对于神经元迁移的机制有了较好的理解。在细胞水平上,神经元迁移需要3个重复事件的精确调控;在分子水平,与神经元迁移相关的胞外信号分子已经被鉴定,而且大量的胞内信号通路也已经被阐明。
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| 关 键 词： | 神经元迁移 c-JNK Cdk5 颤蛋白(reelin) |
Cellular and molecular mechanics of neuronal migration |
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| Ping Wu,Shu-Liang Song,Yun-Shan Wang,Hao Liang,Ai-Guo Ji, International Biotechnology R,D Center,Sh,ong University,Wehai ,China,School of Pharmaceutical Sciences,Jinan. Cellular and molecular mechanics of neuronal migration[J]. Chemistry of Life, 2010, 0(2) |
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| Authors: | Ping Wu Shu-Liang Song Yun-Shan Wang Hao Liang Ai-Guo Ji International Biotechnology R&D Center Sh ong University Wehai China School of Pharmaceutical Sciences Jinan |
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| Affiliation: | Ping Wu1,Shu-Liang Song1,Yun-Shan Wang1,Hao Liang1,Ai-Guo Ji1,2 1International Biotechnology R&D Center,Sh,ong University,Wehai 264209,China,2School of Pharmaceutical Sciences,Jinan 250012 |
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| Abstract: | During the brain development,the correct positioning of neurons is the basis for the proper brain function.In the past decades,our understanding of neuronal migration has been advanced by multidisciplinary approaches.At the cellular level,neuronal migration requires exquisite regulation of three repetitive events.At the molecular level,extracellular guidance cues have been identified and intracellular signal transduction pathways are beginning to be revealed. |
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| Keywords: | neuronal migration c-JNK Cdk5 reelin |
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