Ultraviolet sensitivity ofBacillus subtilis citD mutants |
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Authors: | William F. Burke Jr. Mark McCammon |
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Affiliation: | (1) Department of Botany and Microbiology, Arizona State University, 85281 Tempe, Arizona, USA;(2) Department of Microbiology, Oregon State University, 97331 Corvallis, Oregon, USA |
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Abstract: | Cells ofBacillus subtilis 168 with deletions in thecitD locus were found to be sensitive to irradiation with ultraviolet light and to mitomycin C but were able to repair DNA damage induced by methyl methanesulfonate. The recombination abilities of these cells, as determined by transformation and PBS1-mediated transduction experiments, were unaffected by the deletion. These phenotypic characteristics do not result from a metabolic imbalance caused by the deficiency of a functional α-ketoglutarate dehydrogenase complex, but most likely are a consequence of a genetic locus involved in ultraviolet repair, which is deleted together with thecitK gene when the deletion is formed. |
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