Phylogenetic relationships among transposon-like elements in human and primate DNA |
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Authors: | Julia C. McNaughton Craig J. Marshall Judith E. Broom Gillian Hughes Wyn A. Jones Peter A. Stockwell George B. Petersen |
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Affiliation: | (1) Department of Biochemistry and Centre for Gene Research, University of Otago, 56 Dunedin, New Zealand |
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Abstract: | A THE-1 sequence in intron 7 of the human dystrophin gene has been found to represent a new subfamily of THE-1 elements. The sequence is closely related to the MstII family of repetitive sequences and is more like single-copy sequences found in the galago genome than any other THE-1 sequence previously reported. This new THE-1 sequence has been compared with two other complete THE-1 sequences and three related long-terminal repeat elements that we have previously found in intron 7 of the dystrophin gene, and with members of the same family from elsewhere in the primate genome. Parsimony and deletion analysis show that the cluster of THE-1 sequences in intron 7 of the dystrophin gene has arisen from at least three individual insertion events, rather than from the insertion and duplication of a single progenitor sequence.Correspondence to: G.B. Petersen |
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Keywords: | THE-1 sequences Transposon-like human elements LTR MstII |
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