Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon |
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| Authors: | Saito Yoshio Escuret Vanessa Durantel David Zoulim Fabien Schinazi Raymond F Agrofoglio Luigi A |
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| Institution: | Institut de Chimie Organique et Analytique, ICOA UMR 6005, UFR Sciences, BP 6759, 45067 Cedex 2, Orléans, France. |
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| Abstract: | The synthesis of carbocyclic and phosphonocarbocyclic analogues of ribavirin, an anti-HCV inhibitor, are described. Those compounds were evaluated against HCV but also against other important viruses in order to determine their spectrum of antiviral activity. Compounds 6 and 13 displayed a moderate IC(50) against HIV-1 of 43.8 and 37 microM, respectively. |
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