Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans |
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| Authors: | Kristel Brys Natascha Castelein Filip Matthijssens Jacques R Vanfleteren Bart P Braeckman |
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| Affiliation: | (1) Department of Biology, Ghent University, K L Ledeganckstraat 35, Ghent, B-9000, Belgium |
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| Abstract: | Background The gene daf-2 encodes the single insulin/insulin growth factor-1-like receptor of Caenorhabditis elegans. The reduction-of-function allele e1370 induces several metabolic alterations and doubles lifespan. |
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