Modulation of Carbohydrate Metabolism During <Emphasis Type="Italic">N</Emphasis>-Methyl <Emphasis Type="Italic">N</Emphasis>-Nitrosourea Induced Neurotoxicity in Mice: Role of Curcumin |
| |
Authors: | Neha Singla D K Dhawan |
| |
Institution: | (1) Department of Biophysics, Nuclear Medicine, Panjab University, Chandigarh, India; |
| |
Abstract: | The present study was carried out to elucidate the effectiveness of curcumin in mitigating the adverse effects caused by N-Methyl N-Nitrosourea (MNU) on mouse cerebellum and cerebrum. Male laca mice received either intravenous MNU treatment at a dose of
10 mg/kg bw in sterile double distilled water, curcumin alone 60 mg/kg bw in drinking water, or combined MNU and curcumin
treatment on alternate days for a period of 2 months. The effects of different treatments were studied on carbohydrate metabolizing
enzymes viz: hexokinase, glucose-6-phosphatase (G6P), glucose-6-isomerase (G6I), lactate dehydrogenase (LDH), succinate dehydrogenase
(SDH) and glycogen levels. Curcumin supplementation to MNU treated mice was able to reduce significantly the activities of
the G6P, G6I, hexokinase, LDH, SDH and increased the glycogen contents in both the regions of brain which were altered following
MNU treatment. Hence, curcumin shall prove to be effective in ameliorating the adverse effects caused by MNU. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|