| 胰岛素信号转导通路和衰老研究进展 |
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| 引用本文： | 郭晓强,郭振清. 胰岛素信号转导通路和衰老研究进展[J]. 生物学杂志, 2006, 23(2): 10-12 |
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| 作者姓名： | 郭晓强 郭振清 |
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| 作者单位： | 1. 解放军白求恩军医学院生化教研室,河北,石家庄,050081
2. 河北科技师范学院生命科学系,河北,秦皇岛,066600 |
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| 摘 要： | 衰老是生物学中一个基本的、尚未解决的问题。过去十几年在无脊椎动物方面的研究表明,胰岛素/胰岛素样生长因子信号通路发生改变可以增加寿命和延迟衰老。在酵母、线虫、果蝇和小鼠等方面的研究已经勾画出了这个神秘问题的大致轮廓。
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| 关 键 词： | 衰老 胰岛素 信号转导 |
| 文章编号： | 1008-9632(2006)02-0010-03 |
| 收稿时间： | 2005-04-12 |
| 修稿时间： | 2005-04-12 |
Progress on insulin signal pathway and aging |
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| GUO Xiao-qiang,GUO Zhen-qing. Progress on insulin signal pathway and aging[J]. Journal of Biology, 2006, 23(2): 10-12 |
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| Authors: | GUO Xiao-qiang GUO Zhen-qing |
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| Affiliation: | 1. Department of Biochemistry, Bethune Military Medical College, Hebei Shijiazhuang 050081, China; 2. Department of Life Science, Hebei Normal University of Science and Technology ,Qin huangdao 066600 ,China |
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| Abstract: | Ageing is a fundamental,unsolved mystery in biology.Research with invertebrates over the past 10 years has suggested that alterations in insulin and/or insulin-like growth factor I(IGF-I) signalling resulted in prolonging lifespan and reatrd ageing.Studies on yeast,nematode,fruit fly,and mouse outlined rough mechanism for the mysterious question. |
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| Keywords: | aging insulin signal transduction |
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