Sulfur regulation of the sulfate transporter genes sutA and sutB in Penicillium chrysogenum |
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| Authors: | van de Kamp M Schuurs T A Vos A van der Lende T R Konings W N Driessen A J |
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| Affiliation: | Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9750 AA Haren, The Netherlands. |
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| Abstract: | Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB and sutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin. |
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