No Observable Relationship Between the 12 Genes of Nervous System and Reasoning Skill in a Young Chinese Han Population |
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| Authors: | Pingyuan Gong Fuchang Zhang Xu Lei Xiaodong Wu Dongmei Chen Wenjiang Zhang Kejin Zhang Anyun Zheng Xiaocai Gao |
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| Institution: | (1) Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health, Xi’an, 710069, China;(2) School of Life Science, Institute of Application Psychology, Northwest University, 229 Tai Bai Road, Xi’an, 710069, China;(3) College of Medicine, Henan University of Science and Technology, Luoyang, 471003, China; |
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| Abstract: | Reasoning skill is an advanced cognitive ability which is needed for drawing inferences from given information. It is well
known that the ability depends on the neural network of the frontal and parietal brain regions. In this study, we hypothesized
that some genes involved in neurotransmitter systems were related to reasoning skill. To confirm this hypothesis, we examined
the effects of 13 genes (BDNF, NRSF, COMT, DBH, DRD
2
, DRD
3
, DAT
1
, MAOA, GRM
1, GRIN2B, TPH
2
, 5-HT
2A
, and 5-HT
6
) in neurotransmitter systems on the non-verbal reasoning and verbal reasoning skills. The results indicated there were on
significant effects of the 17 functional variants of these genes on the performance of non-verbal reasoning and verbal analogical
reasoning skills (χ2 > 3.84, df = 1, P > 0.05). This study suggests that some of the functional variations in BDNF, COMT, DBH, DRD
2
, DRD
3
, MAOA, 5-HT
2A
, 5-HT
6
, GRM
1
, and GRIN2B have no observable effects on the certain reasoning skills in a young healthy Chinese Han population. |
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| Keywords: | |
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