Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation |
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Authors: | Navet Rachel Mathy Gregory Douette Pierre Dobson Rowan Laura Leprince Pierre De Pauw Edwin Sluse-Goffart Claudine Sluse Francis E |
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Affiliation: | Laboratory of Bioenergetics, and Centre de Recherche en Neurobiologie Cellulaire et Moléculaire, Liège, Belgium. |
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Abstract: | Cold acclimation induces an adaptative increase in respiration in brown adipose tissue (BAT). A comparative analysis by two-dimensional differential in-gel electrophoresis of mitochondrial protein patterns found in rat control and cold-acclimated BAT was performed. A total of 58 proteins exhibiting significant differences in their abundance was unambiguously identified. Proteins implicated in the major catabolic pathways were up-regulated as were ATP synthase and mitofilin. Moreover, these results support the fact that adipocytes can balance their ATP synthesis and their heat production linked to UCP1-sustained uncoupling. |
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