Abstract: | Background In the present study we have analyzed the mechanisms of calcium entry and mobilization in platelets obtained from rats chronically
treated with the nitric oxide synthesis inhibitor, N-nitro L-arginine methyl ester L-NAME, 40 mg/kg/day, 5 days). The platelets
were obtained the day of the experiment, washed and loaded with fura-2. The intracellular calcium levels were determined in
suspension of cells by means of fluorescence spectroscopy. |