| 哺乳动物不育系20样激酶MST1 |
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| 引用本文： | 许传铭,万福生.哺乳动物不育系20样激酶MST1[J].生命的化学,2011(5). |
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| 作者姓名： | 许传铭 万福生 |
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| 作者单位： | 南昌大学基础医学院生物化学与分子生物学教研室; |
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| 基金项目： | 江西省自然科学基金项目(2010JZY0237)资助 |
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| 摘 要： | 哺乳动物不育系20样激酶1(mammalian sterile 20-like kinase 1,Mst1)基因是果蝇Hippo基因在哺乳动物中的同源基因,编码丝氨酸/苏氨酸激酶,主要参与细胞生长、增殖、凋亡以及器官大小等的调控。最近的研究表明,Mst1基因具有抑癌作用,其功能的缺失与肿瘤的发生密切相关。本文就MST1的结构与功能、促凋亡作用机制及其在医学研究中的应用作一简要综述。
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| 关 键 词： | Mst1 信号转导 细胞凋亡 肿瘤 |
Research progress of MST1 |
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| XU Chuanming,WAN Fusheng.Research progress of MST1[J].Chemistry of Life,2011(5). |
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| Authors: | XU Chuanming WAN Fusheng |
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| Institution: | XU Chuanming,WAN Fusheng Department of Biochemistry and Molecular Biology,Faculty of Basic Medical Science Nanchang University,Nanchang 330006,China |
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| Abstract: | Mst1(Mammalian sterile 20-like kinase 1) is the mammalian homolog of the Drosophila Hippo,a major inhibitor of cell proliferation in Drosophila.It encodes Ser/Thr kinase,and mainly regulates cell growth,proliferation,apoptosis and organ size.Recent studies have shown that Mst1 has tumor-suppressor function,and the deletion or mutation of Mst1 is closely related with tumor.This paper briefly introduces the structure and biological function of MST1,its pro-apoptosis mechanisms and applications in medical rese... |
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| Keywords: | Mst1 signal transduction apoptosis tumor |
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