| 抑癌基因p53与细胞自噬 |
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| 引用本文： | 钱帅伟,漆正堂,支彩霞,丁树哲. 抑癌基因p53与细胞自噬[J]. 生命的化学, 2011, 0(5) |
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| 作者姓名： | 钱帅伟 漆正堂 支彩霞 丁树哲 |
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| 作者单位： | 华东师范大学体育与健康学院线粒体氧化还原应激实验室;郑州大学化学系; |
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| 基金项目： | 国家自然科学基金项目(30871212); 教育部新世纪优秀人才支持计划项目(790013p8)资助 |
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| 摘 要： | 细胞自噬(autophagy)是一种在进化上高度保守的代谢通路,它发生的分子机制和信号调控途径相当复杂,其中mTOR信号通路和Beclin1复合物发挥了最重要的调控作用,p53也是细胞自噬重要的调节因子。研究发现,p53可通过多种途径调节细胞自噬水平,这主要决定于它的亚细胞定位。在细胞核中,p53可通过多种方式上调细胞自噬;而在细胞质中,p53对细胞自噬具有负性调节作用,可抑制细胞自噬的发生。探究清楚p53与细胞自噬之间的调控关系将有助于人类正确认识由于细胞自噬功能异常所诱导的肿瘤的发生发展过程,从而最终攻克各种肿瘤性疾病。
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| 关 键 词： | p53 细胞自噬 信号通路 双重调节 |
Relationship between tumor suppressor gene p53 and autophagy |
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| QIAN Shuaiwei,QI Zhengtang,ZHI Caixia,DING Shuzhe Lab of Mitochondria , Redox Stress,College of Physical Education , Health,East China Normal University,Shanghai ,China. Relationship between tumor suppressor gene p53 and autophagy[J]. Chemistry of Life, 2011, 0(5) |
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| Authors: | QIAN Shuaiwei QI Zhengtang ZHI Caixia DING Shuzhe Lab of Mitochondria Redox Stress College of Physical Education Health East China Normal University Shanghai China |
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| Affiliation: | QIAN Shuaiwei1,QI Zhengtang1,ZHI Caixia2,DING Shuzhe1 1Lab of Mitochondria and Redox Stress,College of Physical Education and Health,East China Normal University,Shanghai 200241,China 2Department of Chemistry,Zhengzhou University,Zhengzhou 450051,China |
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| Abstract: | Autophagy is an evolutionarily conserved catabolic pathway,and its molecular mechanisms and signaling pathways are highly complex.mTOR signaling pathway and Beclin1 are of cardinal significance to autophagy.p53 is also an important regulator which can modulate autophagy by way of multitudes of pathways,dependent on its subcellular localization.Within the nucleus,p53 can positively regulate autophagy,while cytoplasmic p53 inhibits autophagy via multitudes of mechanisms.Accurately understanding the regulatory... |
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| Keywords: | p53 autophagy signaling pathway dual fashion |
| 本文献已被 CNKI 等数据库收录！ |
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