乳腺癌相关基因的甲基化

肿瘤组织中常伴随基因组整体甲基化水平降低和(或)某些基因CpG岛甲基化水平异常升高,这两种变化在肿瘤发生和发展中都扮演着重要的角色。近年来诸多研究报道了CpG岛高甲基化可导致乳腺癌相关的一系列关键基因的表达缺失。由于表观遗传变化存在潜在可逆性,因此,通过检测患者特定基因甲基化状态早期诊断乳腺癌,以及运用甲基化抑制剂来治疗乳腺癌,已成为国内外研究的热点和新思路。

Research progress of methylation of breast cancer related genes

Overall hypomethylation and abnormal hypermethylation of CpG islands in some genes often occur in tumor cells.The two ways play important roles in the carcinogenesis and progression.In recent years,many studies reported CpG island hypermethylation could lead to the expression deletion of key genes in breast cancer.Since the epigenetic changes are potentially reversible,they provide novel insights into the early diagnosis of breast cancer through detecting the methylation status of specific genes in patients...