| YAP与干细胞及肿瘤 |
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| 引用本文： | 古先祥.YAP与干细胞及肿瘤[J].生命的化学,2011(5). |
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| 作者姓名： | 古先祥 |
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| 作者单位： | 张掖医学高等专科学校医学遗传学教研室;复旦大学上海医学院细胞与遗传医学系; |
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| 摘 要： | YAP蛋白作为Hippo信号通路中关键成分,在控制生物器官发育和调控细胞生长中起着十分重要的作用。鉴于YAP蛋白的促细胞生长功能以及过表达YAP或YAP上游调控基因失活将引发肿瘤,YAP因此被认为是原癌蛋白。最新的研究表明YAP在维持干细胞特性、抑制干细胞分化及促进成体细胞重编程中也起着十分重要的作用。可见YAP在干细胞和肿瘤细胞中都扮演着重要角色。因此更好地了解和研究YAP蛋白及其信号通路有助于更好地理解干细胞与肿瘤的关系,有助于干细胞治疗的安全应用以及特异性靶向肿瘤治疗药物的开发。
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| 关 键 词： | YAP蛋白 干细胞 肿瘤 |
Relationship between YAP and stem cells and tumors |
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| GU Xianxiang.Relationship between YAP and stem cells and tumors[J].Chemistry of Life,2011(5). |
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| Authors: | GU Xianxiang |
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| Institution: | GU Xianxiang1,2 1Department of Genetics,Zhangye Medical College,Zhangye 734000,China 2Department of Cellular and Genetic Medicine,Shanghai Medical College of Fudan University,Shanghai 200032,China |
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| Abstract: | YAP is a key protein in Hippo signalling pathway and plays a critical role in organ size regulation and cells growth regulation.YAP was termed as an oncoprotein since YAP was highly expressed in cancer cells,and lose of upstream negative regulation genes of YAP would induce tumors.Recent work have showed that YAP also plays critical roles in stem cells maintenance,inhibition of differentiation of stem cells and induced pluripotent stem cells reprogramming.So YAP plays key roles both in stem cells and tumor ... |
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| Keywords: | YAP protein stem cell tumor |
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