| 基质金属蛋白酶在乳腺癌上皮间质转化中的作用 |
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| 引用本文： | 赵欣,王允山,吉爱国.基质金属蛋白酶在乳腺癌上皮间质转化中的作用[J].生命的化学,2011(5). |
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| 作者姓名： | 赵欣 王允山 吉爱国 |
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| 作者单位： | 山东大学威海分校海洋学院;山东大学威海分校国际生物技术研发中心; |
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| 摘 要： | 基质金属蛋白酶(matrix metalloproteinase,MMP)能够分解并修饰细胞外基质及细胞连接,促进上皮细胞从周围组织中分离出来。在乳腺癌中MMP表达量升高,刺激肿瘤发生,引起癌症细胞的入侵和转移。上皮细胞-间质细胞转化(epithelial-mesenchymal transition,EMT)的激活与肿瘤的发生也有关。最近的研究表明MMP在乳腺的发育和致病的EMT过程中充当促进因子和介质的角色。本文主要概括最新的关于MMP是如何调节乳腺癌细胞的运动、入侵和EMT所驱动的乳腺癌发育的研究,为更好地理解MMP在乳腺癌发病过程中的作用提供依据。
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| 关 键 词： | 基质金属蛋白酶 上皮细胞-间质细胞转化 乳腺癌 蛋白酶抑制剂 |
The role of matrix metalloproteinase in epithelial-mesenchymal transition of breast cancer |
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| ZHAO Xin,WANG Yunshan,JI Aiguo Weihai International Biotechnology Research , Development Center,Weihai Marine College,Sh,ong University,Weihai ,China.The role of matrix metalloproteinase in epithelial-mesenchymal transition of breast cancer[J].Chemistry of Life,2011(5). |
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| Authors: | ZHAO Xin WANG Yunshan JI Aiguo Weihai International Biotechnology Research Development Center Weihai Marine College Sh ong University Weihai China |
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| Institution: | ZHAO Xin,WANG Yunshan,JI Aiguo Weihai International Biotechnology Research and Development Center,Weihai Marine College,Shandong University,Weihai 264209,China |
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| Abstract: | Matrix metalloproteinases(MMPs) degrade and modify the extracellular matrix(ECM) as well as cell-cell contacts,facilitating detachment of epithelial cells from the surrounding tissues.MMPs are upregulated in breast cancer,where they stimulate tumorigenesis,cancer cell invasion and metastasis.The activation of EMT has been implicated in tumor progression.Recent findings have implicated that MMPs act as promoters and mediators of developmental and pathogenic epithelial-mesenchymal transition(EMT) processes in... |
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| Keywords: | matrix metalloproteinase epithelial-mesenchymal transition breast cancer protease inhibitor |
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