| HCV NS3/4A蛋白酶抑制剂细胞筛选模型 |
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| 引用本文： | 丁存宝,刘海燕,李桂秋,吴尚卓,贾长虹.HCV NS3/4A蛋白酶抑制剂细胞筛选模型[J].生命的化学,2011(4). |
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| 作者姓名： | 丁存宝 刘海燕 李桂秋 吴尚卓 贾长虹 |
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| 作者单位： | 河北联合大学生命科学学院;河北联合大学化工学院;遵化市西郊医院; |
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| 摘 要： | 丙型肝炎病毒(hepatitis C virus,HCV)持续感染可导致慢性丙型肝炎,并可发展为肝硬化和肝细胞癌。HCV NS3/4A蛋白酶在HCV复制和致病机制中起着非常关键的作用,已成为HCV研究热点。由于候选药物分子必须具有易进入细胞、稳定性好等特征,建立一种细胞水平上酶活性的测定系统对于筛选抗NS3/4A药物无疑有着重要意义。目前已有多种NS3/4A蛋白酶筛选系统开发出来,本文将对此作一综述。
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| 关 键 词： | 丙型肝炎病毒 NS3/4A蛋白酶 细胞筛选模型 |
The screening system of HCV NS3/4A protease inhibitor |
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| DING Cunbao,LIU Haiyan,LI Guiqiu,WU Shangzhuo,JIA Changhong College of Life Sciences,Hebei United University,Tangshan ,China College of Chemical Engineering,ChinaZunhua Xijiao Hospital,Zunhua ,China.The screening system of HCV NS3/4A protease inhibitor[J].Chemistry of Life,2011(4). |
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| Authors: | DING Cunbao LIU Haiyan LI Guiqiu WU Shangzhuo JIA Changhong College of Life Sciences Hebei United University Tangshan China College of Chemical Engineering ChinaZunhua Xijiao Hospital Zunhua China |
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| Institution: | DING Cunbao1,LIU Haiyan2,LI Guiqiu3,WU Shangzhuo2,JIA Changhong1 1College of Life Sciences,Hebei United University,Tangshan 063009,China 2College of Chemical Engineering,China3Zunhua Xijiao Hospital,Zunhua 063009,China |
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| Abstract: | Hepatitis C virus(HCV) infection is a major cause of chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma(HCC).HCV NS3/4A protease plays an essential role in the HCV replication and pathogenesis,and has become the focus of the HCV research.As the candidate drugs must easily enter the cell and be stable,it was important to construct cell systems to screen NS3/4A proteinase inhibitor.At present,a variety of NS3/4A protease screening systems have been developed.This review discusses the research prog... |
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| Keywords: | hepatitis C virus NS3/4A protease cell screening system |
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