| 鸟氨酸脱羧酶抗酶I与多胺代谢 |
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| 引用本文： | 蔡富强,王艳林.鸟氨酸脱羧酶抗酶I与多胺代谢[J].生命科学,2011(10):1002-1008. |
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| 作者姓名： | 蔡富强 王艳林 |
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| 作者单位： | 三峡大学医学院;三峡大学分子生物学研究所; |
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| 基金项目： | 国家自然科学基金面上项目(30772590) |
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| 摘 要： | 鸟氨酸脱羧酶抗酶I（ornithine decarboxylase antizyme 1,OAZ1）是调节细胞内多胺含量的重要因子,参与细胞生长与分化、胚胎发育、基因表达调控等重要生理过程,也是抗肿瘤治疗的潜在分子靶点。简要综述鸟氨酸脱羧酶抗酶I在结构与功能,及其调控多胺代谢机制方面的研究进展。
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| 关 键 词： | 鸟氨酸脱羧酶抗酶 多胺 代谢调控 肿瘤 |
Ornithine decarboxylase antizyme I and polyamine metabolism |
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| CAI Fu-Qiang,WANG Yan-Lin.Ornithine decarboxylase antizyme I and polyamine metabolism[J].Chinese Bulletin of Life Sciences,2011(10):1002-1008. |
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| Authors: | CAI Fu-Qiang WANG Yan-Lin |
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| Institution: | 1 Medical College,Three Gorges University,Yichang 443002,China;2 Institute of Molecular Biology,Three Gorges University,Yichang 443002,China) |
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| Abstract: | Ornithine decarboxylase antizyme I is an important factor in regulating intracellular polyamine content and involves in cell growth and differentiation,embryonic development,gene expression regulation,and other important physiological processes.It is also a potential molecular target for anti-tumor therapy.This paper reviews the research progress for ornithine decarboxylase antizyme I in the structure,function,and the mechanism for regulating polyamine metabolism. |
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| Keywords: | ornithine decarboxylase antizyme polyamine metabolism regulation tumor |
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