| Reg基因蛋白家族的研究进展 |
| |
| 引用本文： | 刘凤,孙子林,陈平圣,李玲.Reg基因蛋白家族的研究进展[J].生命科学,2011(8):767-772. |
| |
| 作者姓名： | 刘凤 孙子林 陈平圣 李玲 |
| |
| 作者单位： | 东南大学医学院病理教研室;东南大学附属中大医院内分泌科; |
| |
| 基金项目： | 国家自然科学基金项目(30900696); 江苏省自然科学基金项目(BK2009278) |
| |
| 摘 要： | Reg基因蛋白（regenerating gene protein）属于钙依赖的植物血凝素超家族,其功能类似应激蛋白、抗凋亡因子或生长因子。Reg基因蛋白的促进胰岛β细胞分裂和诱导再生作用最早是在糖尿病研究中被发现。Reg基因蛋白在人体多种组织中均表达,与细胞增殖、炎症创伤、感染和神经系统发育关系密切。随着研究的深入,Reg基因蛋白在胰腺损伤修复、神经系统损伤、消化系统肿瘤、脓毒血症及其他疾病中的作用逐渐引起人们重视。
|
| 关 键 词： | Reg基因蛋白 胰腺炎 糖尿病 肿瘤 |
Advances in regenerating gene protein family |
| |
| LIU Feng,SUN Zi-Lin,CHEN Ping-Sheng,LI Ling.Advances in regenerating gene protein family[J].Chinese Bulletin of Life Sciences,2011(8):767-772. |
| |
| Authors: | LIU Feng SUN Zi-Lin CHEN Ping-Sheng LI Ling |
| |
| Institution: | LIU Feng1,SUN Zi-Lin2,CHEN Ping-Sheng1,LI Ling2(1 Department of Pathology,Medical School of Southeast University,Nanjing 210009,China,2 Department of Endocrinology,Zhongda Hospital,Southeast University,China) |
| |
| Abstract: | Regenerating gene proteins（Reg） belong to the calcium-dependent lectin gene superfamily,which act as stress proteins,anti-apoptotic factors,and growth factors.It can induce islet β cell proliferation and promote regeneration,which were initially revealed in the study of diabetes.Reg are expressed in various tissues and involved in cellular proliferation,inflammation,infection and neural development.In recent years,the new role of reg in pancreatic repair,neuronal regeneration,gastrointestinal cancers,and sepsis has spawned significant scientific interests. |
| |
| Keywords: | regenerating gene protein pancreatitis diabetes tumor |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
