The role of mhc polymorphism in anti-microbial resistance |
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| Authors: | Nikolich-Zugich Janko Fremont Daved H Miley Michael J Messaoudi Ilhem |
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| Affiliation: | Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center of the Oregon Health, Science University, OHSU West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA. nikolich@ohsu.edu |
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| Abstract: | The major histocompatibility complex (mhc)-encoded MHC class I and class II molecules present peptide fragments to T cells at every stage of their life (development, survival, persistence and activation). Thereby, these unusually polymorphic molecules critically influence susceptibility to autoimmune and infectious diseases. Here, we examine the mechanistic relationship between mhc polymorphism and anti-microbial resistance/susceptibility. |
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