Characterization of a T suppressor cell line that downgrades experimental allergic encephalomyelitis in mice. |
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| Authors: | W Ofosu-Appiah F Mokhtarian |
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| Institution: | Division of Immunology/Department of Medicine, Maimonides Medical Center, Brooklyn, New York. |
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| Abstract: | A T-suppressor (Ts) cell line of CD8 phenotype was isolated from spleens of SJL/J mice that had recovered from experimental allergic encephalomyelitis (EAE) induced by injection of MBP-activated T cells. The Ts cell line inhibited the proliferation of MBP-sensitized T cells in vitro. Addition of recombinant IL-2 enhanced the Ts-mediated suppression. Adoptively transferred Ts line was able to downgrade EAE in mice subsequently challenged with MBP-activated T cells. The mechanism of suppression appeared to involve neither direct cytolysis of the effector T cells nor the production of a soluble suppressor factor. The findings suggest an in vivo role for suppressor T cells in the regulation of EAE. |
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