Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity |
| |
Institution: | 1. Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8551, Japan;2. Department of Pathology, Faculty of Medicine, Kinki University, Osaka 589-8511, Japan |
| |
Abstract: | The synthetic indole Mannich bases 1–13 have been investigated for their ability to modulate immune responses measured in vitro. These activities were based on monitoring their affects on T-lymphocyte proliferation, reactive oxygen species (ROS), IL (interleukin)-2, IL-4, and nitric oxide production. Compound 5 was found to be the most potent immunomodulator in this context. Four of the synthesized compounds, 5, 11, 12, and 13, have significant potent inhibitory effects on T-cell proliferation, IL-4, and nitric oxide production. However, none of the thirteen indole compounds exerted any activity against ROS production. |
| |
Keywords: | Indole Mannich base ROS Nitric oxide Cytokine inhibition |
本文献已被 ScienceDirect 等数据库收录! |
|