The multifaceted activity of insect caspases |
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Affiliation: | 2. The University of Texas MD Anderson Cancer Center, Smithville, TX, United States;3. MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United States |
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Abstract: | Caspases are frequently considered synonymous with apoptotic cell death. Increasing evidence demonstrates that these proteases may exert their activities in non-apoptotic functions. The non-apoptotic roles of caspases may include developmentally regulated autophagy during insect metamorphosis, as well as neuroblast self-renewal and the immune response. Here, we summarize the established knowledge and the recent advances in the multiple roles of insect caspases to highlight their relevance for physiological processes and survival. |
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Keywords: | Autophagy Cell death Insect evolution Non-apoptotic caspase |
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