Chromatin structure of genes during the cell cycle |
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| Authors: | Zhu Jing-de John Paul |
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| Affiliation: | (1) The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, G61 1BD Glasgow, Scotland;(2) Present address: Department of Biology, Washington University in St. Louis, Campus Box 1137, 63130 St. Louis, MO, USA;(3) Shanghai Institute for Cell Biology, 320 Yue Yang Road, Shanghai, The People's Republic of China |
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| Abstract: | K562 ceils were separated by centrifugal elutriation into 5 fractions each of which had a unique distribution of ceils at different phases of the cell cycle. A study of DNAseI sensitivity of the e- and  -globin genes, which are expressed in these cells, and the  light chain immunoglobulin gene, which is not expressed, in nuclei from each of the 5 fractions was undertaken. There was no detectable difference in the arrangement of DNAseI-hypersensitive sites (DHS) in chromatin of each of the three genes in the different fractions. |
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