Studies on organ weights in naproxen treated rats after intermittent exposure to simulated high altitude |
| |
Authors: | R C Saha H M Biswas |
| |
Institution: | (1) Department of Physiology, University College of Science and Technology, 92, A.P.C. Road, 700009 Calcutta, India |
| |
Abstract: | Rats were exposed intermittently for 8h per day over 6 days at simulated high altitude of 20 000 feet. One group of altitude-exposed animals was treated with naproxen, a prostaglandin inhibiting drug. Significant reduction in body weight gain was observed in both altitude-exposed and drug-treated altitude-exposed animals compared to the control group. Right and left ventricular weights and weights of the adrenal glands were increased significantly in altitude-exposed and altitude-exposed drug-treated animals. The weight of the spleen was increased significantly in altitude-exposed animals whereas no such increase of splenic weight was observed in drug-treated altitude-exposed group of animals. On the other hand, the weight of the liver was decreased significantly in both cases. In drug-treated altitude-exposed animals, the unaltered splenic weight was thought to be due to inhibition of the erythropoietic activity. |
| |
Keywords: | Rats Naproxen Hypoxia Organ weight |
本文献已被 SpringerLink 等数据库收录! |
|