Microsomal lipid peroxidation in human pregnant uterus and placenta |
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| Authors: | G Falkay J Herczeg M Sas |
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| Institution: | Department of Obsterics and Gynecology WHO Collaborative Centre in Clinical Research on Human Reproduction, University Medical School of Szeged, H-6701 Szeged, POB 438 Hungary |
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| Abstract: | A study was made of the microsomal lipid peroxidation of the pregnant human uterus and placenta. It was found that the lipid peroxidation of the microsomal fraction of the uterus is specific for prostaglandin formation: the lipid peroxidation was enhanced by arachidonic acid, and inhibited by anti-prostaglandins. Accordingly, it is suitable as a screening test for the pharmacological examination of anti-prostaglandin effects. The lipid peroxidation in the placenta is not specific. In both tissues examined the lipid peroxidation is linked to ascorbic acid. |
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