Tissue-specific alterations in lipoprotein lipase activity in copper-deficient rats |
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Authors: | Wildman R E Mao S |
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Affiliation: | (1) Nutrition Program, University of Louisiana at Lafayette, P.O. Box 40399, 70504-0399 Lafayette, LA;(2) Ross Laboratories, 625 Cleveland Ave., 43215-1724 Columbus, OH;(3) Department of Food and Nutrition, Ohio University, 108 Tupper Hall, 45701 Athens, OH |
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Abstract: | Copper deficiency results in alterations in lipid metabolism that include elevations in serum cholesterol and triglycerides and a decrease in whole-body respiratory quotient. Copper-deficient animals are also leaner even though electron micrographs of the myocardium present increased lipid droplet accumulation. To address whether a compromised copper status impacts triglyceride deposition in a tissue-specific manner, the activity of lipoprotein lipase was measured in adipose tissue and cardiac and skeletal muscle. Weanling rats fed a copper-restricted diet (<1 ppm) for 6 wk demonstrated a greater than twofold increase in cardiac lipoprotein lipase activity concomitant with a significant reduction in adipose tissue lipoprotein lipase activity. Skeletal muscle lipoprotein lipase activity was not altered by the copper-deficient state. The results of this study suggest that copper deficiency may induce a tissue-specific alteration in lipoprotein lipase activity in rats, which may contribute to the notable deposition of lipid substance in myocardium and the concomitant general body leanness. |
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Keywords: | Copper-deficiency cardiac lipoprotein lipase adipose tissue skeletal muscle |
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