Dual-probe system using pyrenylmethyl-modified amino-LNA for mismatch detection |
| |
Authors: | Umemoto Tadashi Hrdlicka Patrick J Babu B Ravindra Wengel Jesper |
| |
Affiliation: | Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark. tumemoto@riken.jp |
| |
Abstract: | A dual-probe containing pyrenylmethyl amino-LNA has been developed for sensitive mismatch detection. While hybridization with complementary DNA/RNA results in very strong excimer signals, exposure to singly mismatched DNA/RNA targets results in significantly decreased excimer emission. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|