A scanning electron microscopic study of phagocytosis |
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| Authors: | R J Goodall J E Thompson |
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| Affiliation: | 1. Resident, Department of Surgery, Central Finland Central Hospital, Jyväskylä, Finland;2. Professor, Health Sciences, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland;3. Professor, Department of Physical Medicine, Central Finland Health Care District, Jyväskylä, Finland;4. Professor, Department of Plastic Surgery, Central Hospital of Helsinki University, HUS, Helsinki, Finland;5. Orthopaedic Surgeon, Department of Orthopaedics and Traumatology, HUS Helsinki University Hospital and University of Helsinki, Helsinki, Finland |
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| Abstract: | Phagocytosis of latex beads by Acanthamoeba castellanii was examined by scanning electron microscopy. The detailed panoramic views of the cell surface provided by this technique have confirmed the formation of food cups designed to mediate ingestion and have also provided evidence for temporal changes in surface morphology that relate to the accumulation of internalized beads. In particular, the filopodia withdraw and convolutions in the plasma membrane characteristic of cells prior to the initiation of phagocytosis become less distinct. Ultimately the cells re-assume their pre-phagocytotic morphology. The observations suggest that there is surplus plasma membrane some of which is expended during phagocytosis, and that membrane replacement could, therefore, occur after rather than during the most active period of ingestion. |
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