The Affected Sib Method. I. Statistical Features of the Affected Sib-Pair Method |
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Authors: | Uzi Motro and Glenys Thomson |
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Institution: | Genetics Department, Mulford Hall, University of California, Berkeley, California 94720 |
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Abstract: | The distribution of the number of HLA haplotypes shared by sibs affected with the same HLA-linked disease can be used to obtain information on the genetics of the disease. Since the inception of the use of sib-pair methods for the analysis of the HLA-associated diseases, the question has been raised of how to include families with more than two affected sibs in the sib-pair analysis. This paper presents appropriate weighting schemes. A procedure for estimating the frequency of the disease allele in the general population, under the assumptions of single-allele recessive, additive, dominant and intermediate models, with negligible recombination (theta = 0) between the disease-predisposing gene and the HLA region, and no selective disadvantage of the trait, is also given. Cluster-sampling techniques are used in the analysis. |
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